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Brain receptors increase pain resilience in arthritis patients: study


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New study shows people can raise their pain threshold by altering brain chemistry The University of Manchester

Scientists at The University of Manchester have shown for the first time that the numbers of opiate receptors in the brain increases to combat severe pain in arthritis sufferers.

Chronic pain – those that last for more than six months – is a real problem for many people with approximately 46 per cent of the UK population estimated to suffer from it (comprising 20 per cent of consultations in general practice). However, some people seem to cope better than others with pain, and knowing more about how these coping mechanisms work might help to develop new ways of treating this distressing symptom.

It has been known for a long time that we have receptors in our brains that respond to natural painkilling opiates, such as endorphins, but the researchers in Manchester have now shown these receptors increase in number to help cope with long-term, severe pain.


By applying heat to the skin using a laser stimulator, Dr. Christopher Brown and his colleagues showed that the more opiate receptors there are in the brain, the higher the ability to withstand the pain.

The study used Positron Emission Tomography imaging on 17 patients with arthritis and nine healthy controls to show the spread of the opioid receptors.
This suggests that the increase in opiate receptors in the brain is an adaptive response to chronic pain, allowing people to deal with it more easily.

“As far as we are aware, this is the first time that these changes have been associated with increased resilience to pain and shown to be adaptive,” Brown said. “Although the mechanisms of these adaptive changes are unknown, if we can understand how we can enhance them, we may find ways of naturally increasing resilience to pain without the side effects associated with many pain killing drugs.”

Professor Anthony Jones, the director of the Manchester Pain Consortium, which is focused on improving the understanding and treatment of chronic pain, welcomed the results of the study, saying “it changes the way we think about chronic pain.”

“There is generally a rather negative and fatalistic view of chronic pain. This study shows that although the group, as a whole, is more physiologically vulnerable, the whole pain system is very flexible and that individuals can adaptively upregulate their resilience to pain.

“It may be that some simple interventions can further enhance this natural process, and designing smart molecules or simple non-drug interventions to do a similar thing is potentially attractive.”

Val Derbyshire, a patient with arthritis said, “As a patient who suffers chronic pain from osteoarthritis, I am extremely interested in this research. I feel I have developed coping mechanisms to deal with my pain over the years, yet still have to take opioid medication to relieve my symptoms. The fact that this medication has to be increased from time to time concerns me greatly, due to the addictive nature of these drugs. The notion of enhancing the natural opiates in the brain, such as endorphins, as a response to pain, seems to me to be infinitely preferable to long term medication with opiate drugs. Anything that can reduce reliance on strong medication must be worth pursuing.”

Professor of Cognitive Neuroscience at the University, Wael El-Deredy, who is one of the study authors, said, “Receptor imaging is challenging and requires the co-ordination of a large team to collect and analyse the images. We are very lucky to have this technique in Manchester. There are very few places in the world where this study could have been done.”

The paper, Striatal opioid receptor availability is related to acute and chronic pain perception in arthritis: Does opioid adaptation increase resilience to chronic pain?’ is featured in the journal Pain.

The research was funded by the Medical Research Council.

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