Chiropractic + Naturopathic Doctor

Canadian technology aims to help liver cancer treatment in developing nations

By Canadian Chiropractor staff   

Features Clinical Patient Care

Aug. 8, Toronto — London, Ont.-based research firm Centre for Imaging Technology Commercialization (CIMTEC) has teamed up with Western University and Toronto-based Claron Technology to develop hardware and novel software modules to be integrated into an image-guided oncology therapy system that could potentially impact liver cancer treatment in developing countries. 
"This collaborative project has the potential to profoundly impact liver cancer treatment in developing countries such as India, North Asia and part of Europe where access to CT (computed tomography) and MR (magnetic resonance) scanners is extremely limited," said Aaron Fenster, CIMTEC centre director and founding director of the Imaging Research Laboratories at Robarts Research Institute at Western's Schulich School of Medicine and Dentistry. 
"The big advantage is that highly accurate ablations can be performed in a procedure suite, as opposed to a CT scanner, making them more accessible, faster and much cheaper."
Hepatocellular carcinoma (HCC), the most common type of liver cancer, is the fifth most commonly diagnosed malignancy and the third most frequent cause of cancer-related deaths worldwide. In addition, the liver is the second most common site of metastatic cancer arising in other organs, CIMTEC said.
Incidence of HCC is particularly high in Asia and sub-Saharan Africa due to a large number of hepatitis B and C cases in that region. Both hepatitis B and C are complicated by cirrhosis of the liver, which is the greatest risk factor for HCC. Recently, several western countries have been reporting increasing trends in HCC, according to CIMTEC.
Minimally invasive percutaneous techniques, such as radio-frequency and microwave ablation of malignant tissue in the liver, are a rapidly expanding research field and treatment tool for patients who are not candidates for surgical resection or transplant. In some cases this acts as a bridge to liver transplantation. Due to low complication rates, faster recovery times and reported survival rates comparable to resection, the indications for these minimally invasive procedures are continually increasing. However, these methods have a higher local recurrence rate than surgical resection, mostly due to insufficient or inaccurate local ablation of cancerous cells due to the limitations of conventional ultrasound image-guidance, the research company said.
CIMTEC's work on 3D ultrasound-guided focal liver tumour ablation was born out of a project funded through the Ontario Institute for Cancer Research (OICR). OICR's Imaging Translation Program (ITP) team has been addressing the limitations of conventional 2D ultrasound imaging, the most commonly used modality for guiding and monitoring radio-frequency ablation and microwave ablation of liver tumours. 
The new system invented through ITP is based on 3D ultrasound imaging. It will increase the accuracy of identifying and localizing a tumour and reduce, perhaps even eliminate, the need for intra-operative CT imaging, CIMTEC said.
The prototype system showed very positive results during testing in the clinic of interventional radiologist, Nirmal Kakani at London Health Sciences Centre in London, Ont, CIMTEC said. India-based Perfint Healthcare will distribute the new oncology therapy system abroad. 
{mospagebreak}The current phase of the project is partly funded through the International Science and Technology Partnerships (ISTP) Canada program and the Department of Biotechnology India. Mandated by the federal government, ISTP Canada develops and implements research and development collaboration programs under science and technology cooperation agreements between Canada and three of the fastest growing economies in the world: Brazil, China and India. The program connects high commercial potential companies in Canada with similarly positioned companies in each of the three ISTP countries.
Claron Technology, which develops medical imaging softare, is developing the visualization environment or user interface for clinicians. CIMTEC is designing and manufacturing the innovative robotic system and developing four plug-in modules that perform specific tasks, which are assessed and manipulated by the clinician in real time.
The ablation procedure is performed in an ultrasound suite where the ultrasound transducer is moved across the patient's abdomen using the robotic arm. The four CIMTEC-developed modules allow targeted liver tumour ablation in the following sequence:
• 3D CT to 3D ultrasound registration: The procedure is performed in an ultrasound suite where a CT image of a segmented tumour is overlayed onto the 3D ultrasound image.
• Liver tumour segmentation: 3D ultrasound image of the liver and tumour is used to perform semi-automatic segmentation. Any small errors can be corrected using a 3D editing tool.
• A dynamic ablation applicator (needle) is identified and delineated in real time as it is inserted into the tumour: As the physician manually inserts the applicator into the patient, the algorithm automatically tracks the applicator in real time allowing the physician to guide it to the target.
• Static ablation applicator segmentation software is used for verification of the applicator placement before ablation starts: Using manual initialization, the algorithm finds the applicator to verify it is in the correct location within the liver tumour before performing the ablation.
The project is moving ahead to deliver the entire system and up to six functioning units by the end of 2013. The 3D ultrasound-based oncology therapy system will first be tested in a clinical trial in London, Ont. and India. Following a successful trial and approval from the relevant regulatory agencies, it will be made available to hospitals performing liver ablation procedures. With this new technology, patients in developing and developed countries suffering from liver cancers will receive treatment with an accurate and cost-effective technique, CIMTEC said.

Print this page


Stories continue below